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Pharmacokinetics and its Interplay with Alternative Toxicity Methods

1. Pharmacokinetics refers to the assessment of absorption, distribution, metabolism, and excretion (ADME) of chemicals.

A. True B. False

2. Which of the following statements is most accurate?

A. When a new chemical enters the body, the body identifies it as potentially nontoxic and engages systems in many organs to increase its absorption. B. When a new chemical enters the body, the body identifies it as potentially toxic and engages systems in many organs to increase its absorption. C. When a new chemical enters the body, the body identifies it as potentially toxic and engages systems in many organs to decrease its absorption. D. When a new chemical enters the body, the body identifies it as potentially nontoxic and engages systems in many organs to decrease its absorption.

3. A researcher identifies a xenobiotic substance in a human body. Which of the following may be identified as a xenobiotic substance?

A. Human blood B. A synthetic chemical C. Cerebrospinal fluid D. Both A and C

4. It is not standard practice for pharmaceutical companies to include drug-drug interaction information in investigational new drug (IND) submissions.

A. True B. False

5. Which of the following statements is most accurate?

A. The Lautenberg Chemical Safety for the 21st Century Act includes laws which increase the public's access to chemical information. B. The Lautenberg Chemical Safety for the 21st Century Act includes laws which decrease the public's access to chemical information. C. The Lautenberg Chemical Safety for the 21st Century Act includes laws which decrease the public's access to drug-drug interactions. D. The Lautenberg Chemical Safety for the 21st Century Act includes laws which decrease the public's access to research conclusions.

6. Pharmacokinetic models can be divided into the three general groups: experimental (classical) models, physiologically based models and drug-drug models.

A. True B. False

7. Which of the following statements is most accurate?

A. The concepts of systems biology can be used to understand how a chemical affects one system of the human body. B. The concepts of systems biology can be used to understand how a chemical affects the human body as a whole. C. The concepts of systems biology can be used to understand how a chemical affects one cell of the human body. D. The concepts of systems biology can be used to understand how a chemical affects one organ of the human body.

8. Evidence-based methodologies can help improve ADME data rigor and validity.

A. True B. False


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